659: Fulminant Vibrio vulnificus Infection in a Patient With Homozygous Hemochromatosis HFE H63 Mutation

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Homozygous deletion of HFE: the Sardinian hemochromatosis?

22:1-15. 8. Thomas TC, Rollins SA, Rother RP, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996;33:13891401. 9. Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol. 2007;25:1256-1264. 10. Hillmen P...

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Preeclampsia and the C282Y mutation in the hemochromatosis (HFE) gene.

To the Editor: The hemochromatosis (HFE) gene encodes the HFE protein, a transmembrane glycoprotein that is implicated in the modulation of iron uptake from the diet (1 ). The C282Y mutation in this gene is known to be associated with moderately increased serum iron indices. Recently, several studies have described an association between increased maternal iron status and an unfavorable pregnan...

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Diabetes in HFE Hemochromatosis

Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iro...

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A case of Vibrio vulnificus infection complicated with fulminant purpura: gene and biotype analysis of the pathogen

Introduction.Vibrio vulnificus (V. vulnificus) causes a severe infection that develops in the compromised host. Its pathophysiology is classified into three types: (1) primary septicaemia, (2) gastrointestinal illness pattern and (3) wound infection pattern. Of these, primary septicaemia is critical. V. vulnificus can be classified into three biotypes and two genotypes and its pathogenicity is ...

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Cutaneous Injury and Vibrio vulnificus Infection

1. Graves MH, Janda MJ. Rat-bite fever (Streptobacillus moniliformis): a potential emerging disease. Int J Infect Dis. 2001;5: 151–4. 2. Morse SS. Factors in the emergence of infectious disease. Emerg Infect Dis. 1995;1:7–15. 3. Freels LK, Elliott SP. Rat bite fever: three case reports and a literature review. Clin Pediatr (Phila). 2004;43:291–5. 4. Salmon RL, McEvoy MB. Rat-bite fevers. In: Zo...

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ژورنال

عنوان ژورنال: Critical Care Medicine

سال: 2020

ISSN: 0090-3493

DOI: 10.1097/01.ccm.0000728524.65692.58